Decreased antithyroid antibodies during pregnancy in the Hashimoto´s thyroiditis

Abstract

The decrease in antithyroid antibody titer in two cases of Hashimoto's thyroiditis during pregnancy is reported. The two women, aged 37 and 32 years, respectively, diagnosed with Hashimoto's thyroiditis and hypothyroidism, were sequentially evaluated for thyroid function and blood titers of antithyroglobulin (Ac-TG) and antiperoxidase (Ac-TPO) antibodies before, during and after pregnancy. A progressive and significant drop in both antibodies was observed during pregnancy, which was not related to changes in thyroid function. After delivery there was a regrowth of antithyroid antibody titer. It is concluded that during pregnancy there is a decrease in the immune response in Hashimoto's thyroiditis.